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  "Package": "CLME",
  "Title": "Constrained Inference for Linear Mixed Effects Models",
  "Version": "2.0-13",
  "Date": "2026-04-04",
  "Description": "Estimation and inference for linear models where some or\nall of the fixed-effects coefficients are subject to order\nrestrictions. This package uses the robust residual bootstrap\nmethodology for inference, and can handle some structure in the\nresidual variance matrix.",
  "Authors@R": "c(person(\"Casey M.\"  , \"Jelsema\", email=\"jelsema.casey@gmail.com\", role=c(\"aut\", \"cre\") ),\nperson(\"Shyamal D.\", \"Peddada\", role=\"aut\" ))",
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  "BugReports": "https://github.com/jelsema/CLME/issues",
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  "Encoding": "UTF-8",
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  "Repository": "https://jelsema.r-universe.dev",
  "Date/Publication": "2026-04-06 02:49:09 UTC",
  "RemoteUrl": "https://github.com/jelsema/clme",
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    "extra/contents.json",
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  "_realowner": "jelsema",
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  "_releases": [
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      "date": "2014-10-17"
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    "clme",
    "clme_em",
    "clme_em_fixed",
    "clme_em_mixed",
    "clme_resids",
    "create.constraints",
    "fixed.effects",
    "is.clme",
    "lrt.stat",
    "minque",
    "model_terms_clme",
    "random.effects",
    "resid_boot",
    "shiny_clme",
    "shinyServer_clme",
    "shinyUI_clme",
    "VarCorr",
    "w.stat",
    "w.stat.ind"
  ],
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      "name": "fibroid",
      "title": "Fibroid Growth Study",
      "object": "fibroid",
      "file": "fibroid.rda",
      "class": [
        "data.frame"
      ],
      "fields": [
        "id",
        "fid",
        "lfgr",
        "age",
        "loc",
        "bmi",
        "preg",
        "race",
        "vol"
      ],
      "rows": 240,
      "table": true,
      "tojson": true
    },
    {
      "name": "rat.blood",
      "title": "Experiment on mice",
      "object": "rat.blood",
      "file": "rat.blood.csv.gz",
      "class": [
        "data.frame"
      ],
      "fields": [
        "id",
        "time",
        "temp",
        "sex",
        "wbc",
        "rbc",
        "hgb",
        "hct",
        "spun",
        "mcv",
        "mch",
        "mchc",
        "plts"
      ],
      "rows": 198,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "CLME-package",
      "title": "Constrained inference for linear mixed models.",
      "topics": [
        "CLME-package",
        "CLME"
      ]
    },
    {
      "page": "AIC.clme",
      "title": "Akaike information criterion",
      "topics": [
        "AIC.clme",
        "AIC.summary.clme"
      ]
    },
    {
      "page": "BIC.clme",
      "title": "Bayesian information criterion",
      "topics": [
        "BIC.clme",
        "BIC.summary.clme"
      ]
    },
    {
      "page": "clme",
      "title": "Constrained Inference for Linear Mixed Effects Models",
      "topics": [
        "clme"
      ]
    },
    {
      "page": "clme_em",
      "title": "Constrained EM algorithm for linear fixed or mixed effects models.",
      "topics": [
        "clme_em",
        "clme_em_fixed",
        "clme_em_mixed"
      ]
    },
    {
      "page": "clme_resids",
      "title": "Computes various types of residuals",
      "topics": [
        "clme_resids"
      ]
    },
    {
      "page": "confint",
      "title": "Individual confidence intervals",
      "topics": [
        "confint.clme",
        "confint.summary.clme"
      ]
    },
    {
      "page": "create.constraints",
      "title": "Generate common order constraints",
      "topics": [
        "create.constraints"
      ]
    },
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      "page": "fibroid",
      "title": "Fibroid Growth Study",
      "topics": [
        "fibroid"
      ]
    },
    {
      "page": "fixef.clme",
      "title": "Extract fixed effects",
      "topics": [
        "coef.clme",
        "coef.summary.clme",
        "coefficients.clme",
        "coefficients.summary.clme",
        "fixed.effects",
        "fixed.effects.clme",
        "fixed.effects.summary.clme",
        "fixef.clme",
        "fixef.summary.clme"
      ]
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      "page": "formula.clme",
      "title": "Extract formula",
      "topics": [
        "formula.clme"
      ]
    },
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      "page": "as.clme",
      "title": "Constructor method for objects S3 class clme",
      "topics": [
        "as.clme",
        "is.clme"
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    },
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      "title": "Log-likelihood",
      "topics": [
        "logLik.clme",
        "logLik.summary.clme"
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      "title": "Likelihood ratio type statistic (global)",
      "topics": [
        "lrt.stat"
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      "title": "MINQUE Algorithm",
      "topics": [
        "minque"
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      "title": "Create model matrices for 'clme'",
      "topics": [
        "model_terms_clme"
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    },
    {
      "page": "model.matrix.clme",
      "title": "Extract the model design matrix.",
      "topics": [
        "model.matrix.clme",
        "model.matrix.summary.clme"
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      "topics": [
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        "nobs.summary.clme"
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      "page": "plot.clme",
      "title": "S3 method to plot objects of class 'clme'",
      "topics": [
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    },
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      "page": "plot.summary.clme",
      "title": "S3 method to plot objects of class 'clme'",
      "topics": [
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